It would be best to use Optase Protect first for the cleansing and antibacterial action for hygienic care of the eyelids and eyelashes and skin around the eyes, and then the eye cream.
We would recommend using the Optase Protect Spray as per the instructions, wait 1 minute and then wipe off the excess solution with a sterile cotton pad. Then wait a further 10 minutes to use any cream around the eye area.